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Restoring Immune Health and Function with Thymosin Alpha-1

By |2025-02-13T18:53:07-05:00February 13th, 2025|Categories: Peptides|Tags: , , , , , |0 Comments

Your immune system can act as a double-edged sword. When it’s functioning properly, it attacks and eliminates every alien invader that poses a threat to your health, be it a pathogenic bacteria, virus, fungus, or parasite.

When it’s underperforming, you’re at a greater risk of contracting infectious illnesses, including colds, flu, staph infections, e. coli infections, herpes, shingles, salmonella, pneumonia, and the list goes on.

When it’s overperforming, this active system can attack healthy tissues, causing autoimmune disorders, such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, lupus, Hashimoto’s thyroiditis, and Graves’s disease. Then there are other immune disorders that often fly under the radar, triggering chronic inflammatory responses that can cause significant distress.

Graphic for Thymosin Alpha-1

Modern medicine has provided us with numerous medications that can dial up or dial down the immune response. Medications most frequently used for dialing up the immune response are vaccines that trigger a response to specific pathogens that cause common illnesses such as measles, mumps, hepatitis, and polio. Other medications that prompt an immune response include interferon, colony-stimulating factors (CFSs), and monoclonal antibodies. Those medications that dial down the immune response include antihistamines and corticosteroids, among many others.

That being said, there are very few medications or supplements that are effective at both dialing up and dialing down the immune response to restore healthy immune function. Which is why we here at PROVOKE Health often recommend a peptide called Thymosin Alpha-1 (Tα1) to our patients who are struggling with immune system dysfunction or age-related immunosenescence (deterioration of the immune system).

What Is Thymosin Alpha-1

Thymosin Alpha-1 is a zinc-dependent thymus peptide primarily secreted by the thymus. If you’re unfamiliar with peptides, please read The Healing and Rejuvenating Power of Therapeutic Peptides by our founder, Dr. Matthew Lewis, D.C., DACBN, CFMP®, here on the PROVOKE Health blog.

Thymosin Alpha-1 plays a crucial role in modulating immune function, particularly in T-cell differentiation and immune response regulation. (T cells are a type of white blood cell that plays a key role in fighting infections.) Over the years, research into Thymosin Alpha-1 has uncovered its potential applications beyond immunomodulation, including neuroprotection and anti-inflammatory effects.

One of the beneficial applications of Thymosin Alpha-1 is its ability to Continue reading…

Treating Mold Illness in the Aftermath of Hurricanes

By |2024-10-23T20:14:33-04:00October 23rd, 2024|Categories: Mold|Tags: , , , |0 Comments

The 2024 Atlantic hurricane season caused tremendous destruction along Florida’s Gulf Coast, as well as in the mountains of western North Carolina and at multiple points in between, and it may not be over — hurricane season doesn’t officially end until November 30.

Adding to these miseries? Among the most serious health threats for people living in these areas disrupted by surging tides and floodwaters is mold.

Structural damage to homes, schools, and businesses combined with trillions of gallons of water cannot help but to increase exposure to mold toxins, which are universally known to negatively impact health.

If you’ve been spending any amount of time in a water-damaged building (home, school, or workplace), and you’re experiencing any symptoms of exposure to toxic mold, please read on.

Photo for Treating mold illness after a hurricane

Mold Toxicity Symptoms

Let’s start with a list of some of the conditions and symptoms that we commonly see in patients who are suffering from exposure to mold toxins:

  • Brain fog (impaired focus and attention). For more information, read “The Brain Fog Mycotoxin Connection” here on our blog.
  • Fatigue, which may be indicative of chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), depending on its severity (for more information, please read “Chronic Fatigue Syndrome – Healing Your Frustrations!” here on the PROVOKE Health blog)
  • Esophagitis (inflammation of the esophagus, which can cause a sore throat and chest pain)
  • Gastroesophageal reflux disease (GERD)
  • Fibromyalgia
  • Irritable bowel syndrome-mixed (IBS-M), characterized by alternating bouts of constipation and diarrhea (for more information, read “IBS Diagnosis and Treatment Calls for an Understanding of SIBO and SIFO” here on the blog)
  • Small intestinal bacterial overgrowth-small intestinal fungal overgrowth (SIBO-SIFO) or candida yeast overgrowth (a type of SIFO). For more information, read “What Is SIBO and What Can I Do About It?” here on our blog.
  • Dementia
  • Sinusitis (with allergy-like symptoms — sneezing, runny nose, congestion, post-nasal drip)
  • Migraines or less severe but recurring or persistent headaches
  • Multiple sclerosis (MS)
  • Vertigo
  • Postural orthostatic tachycardia syndrome (POTS). For more information, please read “What is Postural Orthostatic Tachycardia Syndrome – or POTS?” here on the PROVOKE Health blog.
  • Sleep disturbances
  • Mast cell activation syndrome (MCAS), which causes allergy-like symptoms (for more information, read “Diagnosing and Treating Mast Cell Activation Syndrome (MCAS)” here on our blog.
  • Lichen sclerosus — a condition that causes patchy, discolored, thin skin, usually in the genital or anal area (for more information, please read “Personalized Treatment for Lichen Sclerosus,”)
  • Dermatitis, swelling of the skin (rashes)
  • Chronic food sensitivities
  • Loss of resilience (increased susceptibility to chronic colds, bronchitis, pneumonia, and other infections)

The list of conditions and symptoms is extensive, partly because mold-related illnesses often go unnoticed by traditional healthcare providers. As a result, those of us who specialize in testing for and treating mold-related illnesses have come to understand its scope in ways that few others do. And here at PROVOKE Health, we don’t guess, we test!

First Steps: Getting an Accurate and Thorough Diagnosis

If you’re experiencing any of the conditions or symptoms described in the previous section, or suffer other unexplained symptoms, you have a choice between two starting points. Begin by having your home inspected, as well as other buildings where you spend time. If toxic mold is suspected, you’ll need to get both your home and yourself tested and treated. If tests come back positive, you’ll want to treat your residence first.

However, if you and your home both test negative, the results will direct our attention to some other cause of your ailments.

At PROVOKE Health, we always start with a thorough evaluation — a physical exam plus an examination of your health history, family history, lifestyle, medications, living environment, and more. This initial examination often reveals factors that we need to take a closer look at by ordering targeted lab tests. Our objective is to keep peeling back “layers of the onion” until we identify the root cause(s) of the symptoms or condition.

For example, a patient may have a vitamin B12 deficiency caused by Continue reading…

Florida is No. 1 in The Nation for Mold — Here’s How to Protect Your Family

By |2024-04-09T21:26:30-04:00April 9th, 2024|Categories: Mold|Tags: , , , , |0 Comments

Florida leads the nation in a number of things, including being the most favored destination for people who are retiring. It’s also the most popular state for new business formations —outside of Delaware, which is a business formation mill. And the Sunshine State is also No. 1 for something called Education Freedom, which enables students and parents a choice of educational options that best meet their needs.

We could go on and on with these “best in the nation” accolades, but this post deals with what we consider one of Florida’s least laudable attributes: mold. Hands down, Florida is No. 1 in nation in mold.

Mold problem in the state of Florida

According to a March 2024 study, Florida scored 38.76 out of a possible 40 on the FDP Mold Index. Mississippi ran a close second at 38.66 and Louisiana came in third with 38.52. FDP’s mold index is based on four key metrics that can be attributed to higher chances of mold growing inside and outside the home:

  • Average rainfall
  • Average temperature
  • Average humidity
  • Average age of homes

Each metric accounts for 10 of the total 40 points.

These scores are no surprise to our medical team here at PROVOKE Health. Many of our patients live in Tampa and other areas in South Central Florida, and their initial visit to our clinic or via a virtual appointment is often because they’re seeking relief from symptoms commonly related to mold exposure. These patients typically have already consulted with conventional medical practices without receiving much, if any, relief. Some of these medical practices don’t even offer a clear diagnosis.

At PROVOKE Health, we provide relief through a highly personalized protocol that addresses everything from in-home testing and mold remediation to blood draws, detoxing, and treating any mold/fungal infection. We calm the inflammatory response and restore health and function to the body’s nervous system, which is often impacted by mold exposure. And while we don’t test homes or perform mold remediation ourselves, we have a list of trusted companies that do as part of our treatment protocol.

Recognizing the Symptoms of Toxic Mold Exposure

Mold exposure can cause infections, especially sinus infections, as well as overwhelm the body’s natural detox mechanisms. Infections and toxins can cause chronic inflammation, which produce symptoms that are vague and difficult to trace back to a clear underlying cause unless you’re a trained medical professional who knows what to look for. Symptoms of mold exposure include, but are not limited to, the following: Continue reading…

The Power of Peptides in Reducing Brain Inflammation

By |2024-03-19T12:47:31-04:00March 19th, 2024|Categories: Brain Health|Tags: , , , , , |0 Comments

Marilyn, an otherwise healthy 45-year-old woman, first visited our functional medicine and integrative healthcare clinic complaining of unrelenting fatigue, brain fog, loss of concentration, difficulty recalling words, and restless sleep.

She had seen other doctors, and they were unable to offer a diagnosis or any effective treatments. Her brain MRI scans came back as normal, and the neurologists with whom she consulted found no notable dementia or neurological disease that could explain her symptoms.

Her nervous system and brain were seemingly intact. All good from the perspective of conventional medicine, but Marilyn knew better; clearly, her brain was not functioning optimally. Marilyn’s symptoms were classic signs of brain inflammation. We had seen these same symptoms in hundreds of patients in the past. We knew the causes, and we had effective treatments to help her.

Peptides for brain inflammation

In this post, we look at common causes of brain inflammation and the PROVOKE Health approach to treatment, which may include the use of medically prescribed therapeutic peptides such as:

  • Semax
  • Selank
  • Thymosin Beta 4

Exploring the Causes of Brain Inflammation

In Marilyn’s case  many of the   common symptoms of brain inflammation were there: exhaustion, clouded thinking and brain fog, poor sleep, anxiety, and a steep decline in quality of life. But before I (Dr. Lewis) go deeper into the specifics of Marilyn’s case, let’s take a look at the bigger picture.

Other Health Conditions Linked to Brain Inflammation

Numerous health conditions can negatively impact brain health and function, including the following: Continue reading…

Chronic Fatigue Syndrome – Healing Your Frustrations!

Have you ever been told it’s all in your head? I mean, did you ever have the feeling that when you speak with your doctor, the look on his or her face is saying “you must be making this all up”? 

In my Tampa holistic and functional medicine practice, I regularly see patients who have many chronic symptoms. Symptoms that on the surface are seemingly unrelated and bizarrely appear to have no known cause. Many of these patients have been diagnosed as Chronic Fatigue Syndrome or exhibit multiple symptoms in multiple systems of the body. It appears as if they have some type of autoimmune condition(s). Although, some have been diagnosed with a specific autoimmune condition, many elude diagnosis. The doctor often suggesting “let’s retest in a few months or a year, it looks autoimmune, but I don’t see anything in your labs yet”. 

Case Study 

A forty year old female administrator recently presented with complaints of memory loss, lack of motivation and anxiety, all brain based symptoms, ok that fits. She explained to me that she has low sex drive, stomach pain, rashes that come and go and is always tired. When, I let her continue to state her concerns, “I also have cramps in my legs and I wake up stiff, my joints hurt, and at times I find it difficult to breathe. I sleep well enough but wake up tired.” There was more! “I have tingling in my hands and I feel weak”. This is suddenly sounding way more complex! 

The patient went on to tell me about her  Continue reading…

Five Gastroenterologists And Not One Stool Test

I recently had a patient whom spent twenty years with chronic GI complaints, visiting greater than five gastrointestinal specialists. In that span of time, not one of the GI specialists ordered a stool test. I found that surprising and too common. The patient found it frustrating!

Can you imagine having a gut issue for over twenty years and no one thought to perform a stool test?

This particular patient had already been through a series of tests including endoscopy, colonoscopy and abdominal sonogram, due to abdominal pain, reflux symptoms and inconsistent bowels ranging from hard or dry stools to watery diarrhea. To be fair, the tests she  had were able to screen for a variety of conditions including celiac, h-pylori infection, gastritis, polyps, colon cancer, and esophagitis to name a few.

However, the patient was told there was no pathology (this basically means your not dying and we can’t find what’s wrong, so you must be ok). The patient was happy to hear she had no pathologies and unhappy with the proposed solution. She was offered  prescription Bentyl and after trying it for several months was unsatisfied with the results.

In my Tampa clinic I use a few different labs to test for GI problems. One such test is the  Continue reading…